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Aradigm to Host Key Opinion Leader Breakfast and Webcast on April 23 in New York City

Event Will Feature a Presentation by KOL David Griffith, MD

HAYWARD, Calif.--(BUSINESS WIRE)-- Aradigm Corporation (NASDAQ:ARDM) ("Aradigm" or the "Company") announced today that it will host a Key Opinion Leader Breakfast on the topic of Non-Cystic Fibrosis Bronchiectasis (non-CF BE) on Thursday, April 23, 2015 from 8:00-9:30 am Eastern Time in New York, NY. The event will feature a presentation by the key opinion leader (KOL) David Griffith, MD.

David E. Griffith, MD, is Professor of Medicine, Pulmonary and Critical Care Division Chief, and Director of the Center for Pulmonary Infectious Disease Control at University of Texas Health Science Center at Tyler (UTHSCT). Since 2002, Dr. Griffith has also held the William A. and Elizabeth B. Moncrief Distinguished Professorship Chair at UTHSCT. In addition to the positions he holds at UTHSCT, Dr. Griffith is the Chief of the Medical Staff at the Texas Center for Infectious Disease (TCID) at San Antonio, Texas, and the Assistant Medical Director for the Heartland National Tuberculosis Center, which is also based at TCID in San Antonio, TX. Dr. Griffith is a globally recognized expert in Bronchiectasis.

Dr. Griffith's current research interests include the epidemiology and treatment of nontuberculous mycobacteria (NTM) diseases, and pathogenesis and treatment of bronchiectasis - a frequent co-morbidity in pulmonary NTM infections. He is author or co-author on more than 180 publications, including original peer reviewed manuscripts, book chapters, reviews, editorials, and electronic publications. His main areas of interest have been the study of mycobacterial diseases, with an emphasis on NTM diseases in patients with bronchiectasis. He has participated in clinical trials and research projects that have resulted in the establishment of treatment standards for NTM disease patients. He was also the principal author for the most recent American Thoracic Society and Infectious Diseases Society of America Guidelines for the Diagnosis, Treatment and Prevention of Nontuberculous Mycobacterial Diseases. UTHSCT is a national referral center for NTM and bronchiectasis patients. Dr. Griffith also provides consultations nationally on mycobacterial diseases and bronchiectasis.

Aradigm's executive management team will provide a corporate overview, including an update on the development program for the investigational drug Pulmaquin® - Aradigm's proprietary inhaled antibiotic product candidate currently in two Phase 3 clinical trials in non-CF BE patients.

Attendance at the Key Opinion Leader Breakfast is limited to institutional investors and analysts. To reserve a space, please contact Veronica Molina at LifeSci Advisors at 212-915-2567.

The presentation, followed by a question-and-answer session, will be webcast live beginning at 8:00 am Eastern Time. The webcast will be accessible live and archived on the Investor Relations section of Aradigm's website at

About Pulmaquin

Ciprofloxacin, available in oral and intravenous formulations, is a widely prescribed antibiotic. It is used to treat acute lung infections and is often preferred because of its broad-spectrum antibacterial activity against various bacteria, such as Pseudomonas aeruginosa. Pulmaquin is an investigational dual release formulation composed of a mixture of liposome encapsulated and unencapsulated ciprofloxacin. It is being evaluated in two ongoing Phase 3 studies to determine its safety and effectiveness as a once-a-day inhaled formulation for the chronic treatment of non-cystic fibrosis bronchiectasis (non-CF BE).

Pulmaquin has been tested in preclinical safety studies (up to 3 months in rodents and 9 months in dogs).

Following Phase 2a development of the liposomal portion of Pulmaquin (Lipoquin®) and Phase 1 development of Pulmaquin, the Phase 2b study ORBIT-2 with Pulmaquin was a 24-week multicenter, randomized, double-blind, placebo-controlled trial in 42 adult non-CF BE subjects. This study demonstrated a significant reduction in P.aeruginosa sputum activity (p=0.002) and a decrease in time to first exacerbation in the per protocol population (p=0.046) and the mITT (p=0.057) populations in the Pulmaquin treated subjects compared to placebo. Overall, the incidence of all treatment emergent adverse events was similar between groups. The most frequently reported treatment related adverse events (reported by ≥ 3 patients in either treatment group) included product taste abnormal and nausea in the Pulmaquin group and wheezing in the placebo group. No serious adverse events were considered treatment related. There were no deaths reported during ORBIT-2.

The Phase 3 clinical program for Pulmaquin in non-CF BE consists of two worldwide, double-blind, placebo-controlled pivotal trials (ORBIT-3 and ORBIT-4) that are identical in design except for a pharmacokinetics sub-study to be conducted in one of the trials. Each trial is enrolling approximately 255 patients into a 48 week double-blind period consisting of 6 cycles of 28 days on treatment with Pulmaquin or placebo plus 28 days off treatment, followed by a 28 day open label extension in which all participants will receive Pulmaquin (total treatment duration approximately one year). The superiority of Pulmaquin vs. placebo during the double-blind period is being evaluated in terms of the time to first pulmonary exacerbation (primary endpoint), while key secondary endpoints include the reduction in the number of pulmonary exacerbations and improvements in the quality of life measures. Lung function is being monitored as a safety indicator.

Aradigm has been granted orphan drug designations for liposomal ciprofloxacin, as well as for ciprofloxacin for inhalation for non-CF BE in the U.S. In addition, the U.S. Food and Drug Administration (FDA) has designated Pulmaquin as a Qualified Infectious Disease Product (QIDP). The QIDP designation is granted for treatment of non-CF BE patients with chronic lung infections with Pseudomonas aeruginosa. The QIDP designation made Pulmaquin eligible for Fast Track designation which was granted by the FDA in September 2014.

In 2013, Aradigm granted an exclusive, world-wide license for the Company's inhaled liposomal ciprofloxacin product candidates for the indication of non-CF BE and other indications to Grifols S.A. More information on the terms of this license may be found in the Company's Annual Report on Form 10-K for the year ended December 31, 2013 filed with the SEC on March 13, 2014.

About Non-Cystic Fibrosis Bronchiectasis

Non-CF BE is a severe, chronic and rare disease characterized by abnormal dilatation of the bronchi and bronchioles, frequently associated with chronic lung infections. It is often a consequence of a vicious cycle of inflammation, recurrent lung infections, and bronchial wall damage. Non-CF BE represents an unmet medical need with high morbidity and mortality that affects more than 110,000 people in the U.S. and over 200,000 people in Europe. There is currently no drug approved for the treatment of this condition.

About Aradigm

Aradigm is an emerging specialty pharmaceutical company focused on the development and commercialization of drugs delivered by inhalation for the prevention and treatment of severe respiratory diseases. Aradigm has product candidates under development for the treatment of non-CF BE, cystic fibrosis and prevention of respiratory and other diseases in tobacco smokers through smoking cessation. Aradigm is also developing Pulmaquin and a liposomal ciprofloxacin formulation as potential medications for patients with chronic lung infections with non-tuberculous mycobacteria (NTM), and for the prevention and treatment of high threat and bioterrorism infections, such as inhaled tularemia, pneumonic plague, Q fever and inhaled anthrax.

More information about Aradigm can be found at

Forward-Looking Statements

Except for the historical information contained herein, this news release contains forward-looking statements that involve risk and uncertainties, including those related to the ORBIT-3 and ORBIT-4 clinical trials and the ability to continue successful product development of our potential product candidates, including Pulmaquin, as well as the other risks detailed from time to time in the Company's filings with the Securities and Exchange Commission (SEC), including the Company's Annual Report on Form 10-K for the year ended December 31, 2014 filed with the SEC on March 18, 2015, and the Company's Quarterly Reports on Form 10-Q.

Aradigm, Pulmaquin, Lipoquin and the Aradigm Logo are registered trademarks of Aradigm Corporation.

Aradigm Corporation
Nancy Pecota, 510-265-8800
Chief Financial Officer
LifeSci Advisors, LLC
Andrew McDonald, 646-597-6987
Founding Partner

Source: Aradigm Corporation

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